The word Pneumonoultramicroscopicsilicovolcanoconiosis is defined as "a lung disease caused by the inhalation of very fine silica dust, mostly found in volcanos". It was originally coined simply to serve as the longest English word, but has been used in several sources as an approximation of its originally intended definition. The name generally used to describe this condition is pneumoconiosis, which is much shorter.
Here is another interesting one ....
Honorificabilitudinitatibus is a word used by Costard in act five, scene one of William Shakespeare's Love's Labour's Lost. It is (in the quote) the ablative plural of the medieval Latin word honorificabilitudinitas, which can be translated as "the state of being able to achieve honours." Appearing only once in Shakespeare's works, it is a hapax legomenon.
"O, they have lived long on the alms-basket of words.
I marvel thy master hath not eaten thee for a word;
for thou art not so long by the head as
honorificabilitudinitatibus: thou art easier
swallowed than a flap-dragon."
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